g protein-coupled receptors — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21874	CID 2745687		GPR
	CID 2745687 is a GPR35 antagonist that inhibited the effects at human GPR35 of cromolyn disodium and zaprinast, two agonists that share an overlapping binding site.		GPR
T14046	Anandamide	(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor , Endogenous Metabolite
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous sy...		Cannabinoid Receptor , Endogenous Metabolite
TP1051L	Protein Kinase C Peptide Substrate acetate	Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)	Others
	Protein Kinase C Peptide Substrate acetate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-couple...		Others
T50088	N-phenylthiophene-2-carboximidamide		Others
	N-phenylthiophene-2-carboximidamide is a thiophene derivative that functions as an inhibitor of protein tyrosine kinases (PTKs) and a ligand for G protein-coupled receptors (GPCRs).		Others
TP1074L	Neuropeptide FF acetate(99566-27-5 free base)	NPFF acetate	Neuropeptide Y Receptor
	Neuropeptide FF acetate(99566-27-5 free base) (NPFF acetate) is an octapeptide belonging to the RF amide family. NPFF interacts with G-protein-coupled receptors NPFF (1) and NPFF (2).		Neuropeptide Y Receptor
T9857L	Vasopressin acetate	Vasopressin acetate (11000-17-2 Free base)	Endogenous Metabolite
	Vasopressin acetate, a cyclic nonapeptide, is synthesized centrally in the hypothalamus. Vasopressin acetate acts as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.		Endogenous Metabolite
T38807L	[Lys8, Lys9]-Neurotensin (8-13) acetate		Neurotensin Receptor
	[Lys8, Lys9]-Neurotensin (8-13) acetate, a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 r...		Neurotensin Receptor
T3232	Higenamine hydrochloride	Higenamine HCl,Demethylcoclaurine hydrochloride,norcoclaurine HCl,(+-)-Demethylcoclaurine hydrochloride,Higenamine Hydrochloride	Adrenergic Receptor
	Higenamine hydrochloride (norcoclaurine HCl) has been demonstrated to be a β2 adrenoreceptor agonist. Adrenergic receptors, or adrenoceptors, belong to the class of G protein–coupled receptors, and are the most prominent...		Adrenergic Receptor
TP1914L1	BAM (8-22) acetate	BAM (8-22) acetate(412961-36-5 free base)	Others
	BAM (8-22) acetate is a proteolytically cleaved product of proenkephalin A. BAM (8-22) acetate activates Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr...		Others
T38651	Lauryl maltose neopentyl glycol	LMNG
	Lauryl maltose neopentyl glycol (LMNG) is a detergent that solubilizes and stabilizes membrane proteins. lauryl maltose neopentyl glycol extracts intact membrane proteins from membranes, thereby improving the stability o...
T38287	C3a Receptor Agonist	C3a receptor agonist 1,Complement 3a Receptor Agonist	Complement System
	C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestin...		Complement System
T9857	Vasopressin	antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP)	Endogenous Metabolite
	Vasopressin (argipressin), a cyclic nine-peptide synthesized by hypothalamic neurons, is one of the hormones involved in peptide prohormone synthesis. Vasopressin is involved in the regulation process of hypothalamic-pit...		Endogenous Metabolite
TP1051	Protein Kinase C Peptide Substrate	PRKCE,Peptide Epsilon,PKCε
	Protein Kinase C Peptide Substrate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-coupled recept...
T39165	Treprostinil palmitil	Treprostinil palmitil,INS-1009
	Treprostinil Palmitil (TP), a prodrug of the DP1 and EP2 agonist Treprostinil (UT-15), exhibits EC50 values of 0.6 and 6.2 nM, respectively. It is a pure prodrug without any inherent binding affinity for G-protein couple...
T26200	Somatostatin RC 102	Somatostatin RC102,Somatostatin-RC-102,Somatostatin RC-102
	Somatostatin RC 102 is a peptide hormone. It regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release...
T38807	[Lys8, Lys9]-Neurotensin (8-13)	JMV438,[Lys8, Lys9]-Neurotensin (8-13)
	[Lys8, Lys9]-Neurotensin (8-13) (JMV438) is a Neurotensin analog that elicits analgesic effects by activating the G protein-coupled receptors NTS1 and NTS2. The compound has K i values of 0.33 nM and 0.95 nM for hNTS1 an...
T39976	MS67		PROTACs
	MS67 is a potent and selective degrader of the WD40 repeat domain protein 5 (WDR5) with a dissociation constant (Kd) of 63 nM. It exhibits no activity against protein methyltransferases, kinases, G-protein-coupled recept...		PROTACs
T80197	Vasopressin Dimer (parallel) (TFA)		Vasopressin Receptor
	Vasopressin Dimer (parallel) TFA, a parallel dimer of Vasopressin, has the capability to activate four G protein-coupled receptors—namely, V1aR, V1bR, V2R, and OTR [1].		Vasopressin Receptor
T83547	(Des-Bromo)-Neuropeptide B (1-23) (human)
	'(Des-Bromo)-Neuropeptide B (1-23) (human)' is an agonist for orphan G-protein-coupled receptors, exhibiting a K i of 1.2 nM for GPR7 (NPBW1) and 341 nM for GPR8 (NPBW2) respectively [1].
T62444	NBI-27914
	NBI-27914 is a potent and selective CRFR1 antagonist. The CRF receptors CRFR1 and CRFR2 are members of the G protein-coupled receptor superfamily.